Complement Proteins C5/C5a, Cathepsin D and Prolactin in Chondrocytes: A Possible Crosstalk in the Pathogenesis of Osteoarthritis

Complement Proteins C5/C5a, Cathepsin D and Prolactin in Chondrocytes: A Possible Crosstalk in the Pathogenesis of Osteoarthritis

Introduction: Both increased activity of the complement system (CS) and the role of the pituitary hormone prolactin (PRL) are implicated in osteoarthritis (OA) pathogenesis. Besides, Cathepsin D (CatD) activity is increased in the context of OA and can exert not only proteolytic but also non-proteol...

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Bibliographic Details
Main Authors: Sandeep Silawal, Miriam Wagner, Dominik Roth, Thomas Bertsch, Silke Schwarz, Maximilian Willauschus, Markus Gesslein, Jakob Triebel, Gundula Schulze-Tanzil
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
osteoarthritis
complement
C5
anaphylatoxin C5a
prolactin
prolactin receptor
Online Access:https://www.mdpi.com/2073-4409/11/7/1134

Internet

https://www.mdpi.com/2073-4409/11/7/1134

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