KPC pancreatic cancer cells are a novel immunocompetent murine model supporting human adenovirus replication and tumor oncolysis

KPC pancreatic cancer cells are a novel immunocompetent murine model supporting human adenovirus replication and tumor oncolysis

Oncolytic adenoviral therapy is a promising approach for pancreatic cancer treatment. However, the limited capacity of murine cells to produce infectious viral progeny precludes the full evaluation of the virotherapy in a suitable immunocompetent mouse model. Here, we report that the murine KPC-I ce...

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Bibliographic Details
Main Authors: Marc Otero-Mateo, Francesc Estrany Jr, Sabrina Arcas-Márquez, Laura Moya-Borrego, Giancarlo Castellano, Miquel Castany, Ramon Alemany, Cristina Fillat
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Oncology
Subjects:
oncolytic adenovirus
immunocompetent models
pancreatic tumors
KPC cells
autophagy
adenovirus replication
Online Access:http://www.sciencedirect.com/science/article/pii/S295032992400170X

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http://www.sciencedirect.com/science/article/pii/S295032992400170X

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