Dose optimization in surgical prophylaxis: sub-inhibitory dosing of vancomycin increases rates of biofilm formation and the rates of surgical site infection

Abstract Antibiotic stewardship is viewed as having great public health benefit with limited direct benefit to the patient at the time of administration. The objective of our study was to determine if inappropriate administration of antibiotics could create conditions that would increase the rates o...

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Bibliographic Details
Main Authors: Kimberly M. Brothers, Dana M. Parker, Masashi Taguchi, Dongzhu Ma, Jonathan B. Mandell, Lance L. Thurlow, Venkata C. Byrapogu, Kenneth L. Urish
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-30951-y