Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model
Maternal immune activation (MIA) is a risk factor for schizophrenia in the offspring. MIA in pregnant rodents can be induced by injection of synthetic polyriboinosinic-polyribocytidilic acid (Poly I:C), which causes decreased striatal dopamine D2 receptor (D2R) expression and behavioral dysfunction...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354622000369 |
| _version_ | 1818554675241156608 |
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| author | Arata Oh-Nishi Yuji Nagai Chie Seki Tetsuya Suhara Takafumi Minamimoto Makoto Higuchi |
| author_facet | Arata Oh-Nishi Yuji Nagai Chie Seki Tetsuya Suhara Takafumi Minamimoto Makoto Higuchi |
| author_sort | Arata Oh-Nishi |
| collection | DOAJ |
| description | Maternal immune activation (MIA) is a risk factor for schizophrenia in the offspring. MIA in pregnant rodents can be induced by injection of synthetic polyriboinosinic-polyribocytidilic acid (Poly I:C), which causes decreased striatal dopamine D2 receptor (D2R) expression and behavioral dysfunction mediated by the dopaminergic system in the offspring. However, previous studies did not determine whether Poly I:C induced cortical dopamine D2R abnormality in an MIA rat model. In this study, we performed micro-positron emission tomography (micro-PET) in vivo imaging and ex vivo neurochemical analyses of cortical D2Rs in MIA. In the micro-PET analyses, the anterior cingulate cortex (ACC) region in the offspring showed significantly reduced binding potential for [11C]FLB457, a high affinity radio-ligand toward D2Rs. Neurochemical analysis showed reduction of D2Rs and augmentation of dopamine turnover in the ACC of the rat offspring. Thus, MIA induces dopaminergic dysfunction in the ACC of offspring, similar to the neuronal pathology reported in patients with schizophrenia. |
| first_indexed | 2024-12-12T09:43:06Z |
| format | Article |
| id | doaj.art-296e3bf993cc4e2fa09a2c9bd1817497 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-12-12T09:43:06Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-296e3bf993cc4e2fa09a2c9bd18174972022-12-22T00:28:29ZengElsevierBrain, Behavior, & Immunity - Health2666-35462022-07-0122100446Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat modelArata Oh-Nishi0Yuji Nagai1Chie Seki2Tetsuya Suhara3Takafumi Minamimoto4Makoto Higuchi5Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, Japan; Division of Immune-Neuropsychiatry, Faculty of Medicine, Shimane University, Shimane, 693-8501, Japan; RESVO Inc., Kawasaki, 210-007, Japan; Corresponding author. Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555 Japan.Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, JapanDepartment of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, JapanDepartment of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, JapanDepartment of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, JapanDepartment of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, JapanMaternal immune activation (MIA) is a risk factor for schizophrenia in the offspring. MIA in pregnant rodents can be induced by injection of synthetic polyriboinosinic-polyribocytidilic acid (Poly I:C), which causes decreased striatal dopamine D2 receptor (D2R) expression and behavioral dysfunction mediated by the dopaminergic system in the offspring. However, previous studies did not determine whether Poly I:C induced cortical dopamine D2R abnormality in an MIA rat model. In this study, we performed micro-positron emission tomography (micro-PET) in vivo imaging and ex vivo neurochemical analyses of cortical D2Rs in MIA. In the micro-PET analyses, the anterior cingulate cortex (ACC) region in the offspring showed significantly reduced binding potential for [11C]FLB457, a high affinity radio-ligand toward D2Rs. Neurochemical analysis showed reduction of D2Rs and augmentation of dopamine turnover in the ACC of the rat offspring. Thus, MIA induces dopaminergic dysfunction in the ACC of offspring, similar to the neuronal pathology reported in patients with schizophrenia.http://www.sciencedirect.com/science/article/pii/S2666354622000369Maternal immune activationSchizophreniaDopamine D2 receptorsDopamineAnterior cingulate cortexPoly I:C |
| spellingShingle | Arata Oh-Nishi Yuji Nagai Chie Seki Tetsuya Suhara Takafumi Minamimoto Makoto Higuchi Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model Brain, Behavior, & Immunity - Health Maternal immune activation Schizophrenia Dopamine D2 receptors Dopamine Anterior cingulate cortex Poly I:C |
| title | Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model |
| title_full | Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model |
| title_fullStr | Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model |
| title_full_unstemmed | Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model |
| title_short | Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model |
| title_sort | imaging extra striatal dopamine d2 receptors in a maternal immune activation rat model |
| topic | Maternal immune activation Schizophrenia Dopamine D2 receptors Dopamine Anterior cingulate cortex Poly I:C |
| url | http://www.sciencedirect.com/science/article/pii/S2666354622000369 |
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