Vaccine Increases the Diversity and Activation of Intratumoral T Cells in the Context of Combination Immunotherapy

Vaccine Increases the Diversity and Activation of Intratumoral T Cells in the Context of Combination Immunotherapy

Resistance to immune checkpoint blockade therapy has spurred the development of novel combinations of drugs tailored to specific cancer types, including non-inflamed tumors with low T-cell infiltration. Cancer vaccines can potentially be utilized as part of these combination immunotherapies to enhan...

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Bibliographic Details
Main Authors: Lucas A. Horn, Kristen Fousek, Duane H. Hamilton, James W. Hodge, John A. Zebala, Dean Y. Maeda, Jeffrey Schlom, Claudia Palena
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
cancer vaccine
combination immunotherapy
TCR diversity
Online Access:https://www.mdpi.com/2072-6694/13/5/968

Internet

https://www.mdpi.com/2072-6694/13/5/968

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