The α-dystrobrevins play a key role in maintaining the structure and function of the extracellular matrix–significance for protein elimination failure arteriopathies

The α-dystrobrevins play a key role in maintaining the structure and function of the extracellular matrix–significance for protein elimination failure arteriopathies

Abstract The extracellular matrix (ECM) of the cerebral vasculature provides a pathway for the flow of interstitial fluid (ISF) and solutes out of the brain by intramural periarterial drainage (IPAD). Failure of IPAD leads to protein elimination failure arteriopathies such as cerebral amyloid angiop...

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Bibliographic Details
Main Authors: Matthew MacGregor Sharp, Jordan Cassidy, Thomas Thornton, James Lyles, Abby Keable, Maureen Gatherer, Masato Yasui, Yoichiro Abe, Shinsuke Shibata, Roy O. Weller, Dariusz C. Górecki, Roxana O. Carare
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Acta Neuropathologica Communications
Online Access:https://doi.org/10.1186/s40478-021-01274-8

Internet

https://doi.org/10.1186/s40478-021-01274-8

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