MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma

MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma

Abstract Retinoblastoma is a rare, intraocular paediatric cancer that originates in the neural retina and is most frequently caused by bi-allelic loss of RB1 gene function. Other oncogenic mutations, such as amplification and increased expression of the MYCN gene, have been found even with proficien...

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Bibliographic Details
Main Authors: Maria K. E. Blixt, Minas Hellsand, Dardan Konjusha, Hanzhao Zhang, Sonya Stenfelt, Mikael Åkesson, Nima Rafati, Tatsiana Tararuk, Gustav Stålhammar, Charlotta All-Eriksson, Henrik Ring, Finn Hallböök
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-022-00409-3

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https://doi.org/10.1038/s41389-022-00409-3

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