Usage of adenovirus expressing thymidine kinase mediated hepatocellular damage for enabling mouse liver repopulation with allogenic or xenogenic hepatocytes.

Usage of adenovirus expressing thymidine kinase mediated hepatocellular damage for enabling mouse liver repopulation with allogenic or xenogenic hepatocytes.

It has been shown that the liver of immunodeficient mice can be efficiently repopulated with human hepatocytes when subjected to chronic hepatocellular damage. Mice with such chimeric livers represent useful reagents for medical and clinical studies. However all previously reported models of humaniz...

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Bibliographic Details
Main Authors: Daniel Moreno, Anangi Balasiddaiah, Oscar Lamas, Cedric Duret, Leire Neri, Laura Guembe, Miguel Galarraga, Esther Larrea, Martine Daujat-Chavanieu, Jordi Muntane, Patrick Maurel, Jose Ignacio Riezu, Jesus Prieto, Rafael Aldabe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3782477?pdf=render

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http://europepmc.org/articles/PMC3782477?pdf=render

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