Characterization of caffeine response regulatory variants in vascular endothelial cells

Characterization of caffeine response regulatory variants in vascular endothelial cells

Genetic variants in gene regulatory sequences can modify gene expression and mediate the molecular response to environmental stimuli. In addition, genotype–environment interactions (GxE) contribute to complex traits such as cardiovascular disease. Caffeine is the most widely consumed stimulant and i...

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Bibliographic Details
Main Authors: Carly Boye, Cynthia A Kalita, Anthony S Findley, Adnan Alazizi, Julong Wei, Xiaoquan Wen, Roger Pique-Regi, Francesca Luca
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-02-01
Series:eLife
Subjects:
genotype-environment interaction
massively parallel reporter assay
gene regulation
caffeine
cardiovascular disease
allele-specific expression
Online Access:https://elifesciences.org/articles/85235

Internet

https://elifesciences.org/articles/85235

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