Cyclophosphamide Regulates N6-Methyladenosine and m6A RNA Enzyme Levels in Human Granulosa Cells and in Ovaries of a Premature Ovarian Aging Mouse Model

Cyclophosphamide Regulates N6-Methyladenosine and m6A RNA Enzyme Levels in Human Granulosa Cells and in Ovaries of a Premature Ovarian Aging Mouse Model

Cyclophosphamide (CTX) is one of the most frequently used alkylating anticancer drugs. CTX is associated with reproductive failure and premature ovarian insufficiency (POI) or premature ovarian aging. Much less is known about the mechanism by which CTX affects female fertility through N6-methyladeno...

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Bibliographic Details
Main Authors: Boxian Huang, Chenyue Ding, Qinyan Zou, Wei Wang, Hong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Endocrinology
Subjects:
cyclophosphamide
m6A
RNA methyltransferase
RNA demethylase
RNA effector
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00415/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00415/full

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