Molecular Analysis: Microsatellite Instability and Loss of Heterozygosity of Tumor Suppressor Gene in Hereditary Non-Polyposis Colorectal Cancer (HNPCC)

Molecular Analysis: Microsatellite Instability and Loss of Heterozygosity of Tumor Suppressor Gene in Hereditary Non-Polyposis Colorectal Cancer (HNPCC)

HNPCC (Hereditary non-polyposis colorectal cancer) development is caused by mutation of genes included in system of mismatch repair genes. The mutation exists at 60% of patients in hMSH2 gene, 30% in hMLH1 and 10% both in hPMS1and hPMS2 genes. RER+ exists in about 90% in hereditary non-polyposis col...

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Bibliographic Details
Main Authors: Vesna Hadžiavdić, Nada Pavlović-Čalić, Izet Eminović
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2009-02-01
Series:Biomolecules & Biomedicine
Subjects:
HNPCC
microsatellite instability
loss of heterozygosity
RER phenotype
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/2850

Internet

https://www.bjbms.org/ojs/index.php/bjbms/article/view/2850

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