Overcoming acquired resistance to cancer immune checkpoint therapy: potential strategies based on molecular mechanisms

Overcoming acquired resistance to cancer immune checkpoint therapy: potential strategies based on molecular mechanisms

Abstract Immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1/PD-L1 to boost tumor-specific T lymphocyte immunity have opened up new avenues for the treatment of various histological types of malignancies, with the possibility of durable responses and improved survival. However, the develop...

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Bibliographic Details
Main Authors: Bin Wang, Yin Han, Yuyu Zhang, Qin Zhao, Huanhuan Wang, Jinlong Wei, Lingbin Meng, Ying Xin, Xin Jiang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cell & Bioscience
Subjects:
Immune checkpoint inhibitors
Acquired resistance
Mechanisms
Tumor microenvironment
Combination therapy
Online Access:https://doi.org/10.1186/s13578-023-01073-9

Internet

https://doi.org/10.1186/s13578-023-01073-9

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