Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice
Here we investigate the regulation of hepcidin, a hormone that inhibits dietary iron absorption and macrophage iron recycling, by the serum iron-binding protein transferrin. Mice deficient in transferrin (Tfhpx/hpx) and hemojuvelin (Hjv−/−), a gene mutated in juvenile hemochromatosis, a disease of h...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2012-02-01
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| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/6205 |