The physiological metabolite α-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress

The physiological metabolite α-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress

Osteoarthritis (OA) is an age-related metabolic disease. Low-grade inflammation and oxidative stress are the last common pathway of OA. α-ketoglutarate (α-KG) is an essential physiological metabolite from the mitochondrial tricarboxylic acid (TCA) cycle, with multiple functions, including anti-infla...

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Bibliographic Details
Main Authors: Liang Liu, Wanying Zhang, Tanghao Liu, Yangfan Tan, Cheng Chen, Jun Zhao, Huan Geng, Chi Ma
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
α-ketoglutarate
Osteoarthritis
Cartilage
Mitophagy
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000642

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http://www.sciencedirect.com/science/article/pii/S2213231723000642

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