The physiological metabolite α-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress

The physiological metabolite α-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress

Osteoarthritis (OA) is an age-related metabolic disease. Low-grade inflammation and oxidative stress are the last common pathway of OA. α-ketoglutarate (α-KG) is an essential physiological metabolite from the mitochondrial tricarboxylic acid (TCA) cycle, with multiple functions, including anti-infla...

Full description

Bibliographic Details
Main Authors:	Liang Liu, Wanying Zhang, Tanghao Liu, Yangfan Tan, Cheng Chen, Jun Zhao, Huan Geng, Chi Ma
Format:	Article
Language:	English
Published:	Elsevier 2023-06-01
Series:	Redox Biology
Subjects:	α-ketoglutarate Osteoarthritis Cartilage Mitophagy Oxidative stress
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231723000642

Similar Items

α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice
by: Hao Yu, et al.
Published: (2024-01-01)

Regulating Effect of Exogenous α-Ketoglutarate on Ammonium Assimilation in Poplar
by: Xiaoning Liu, et al.
Published: (2024-03-01)

α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway
by: Rong He, et al.
Published: (2024-06-01)

Energy Metabolites and Indicative Significance of α-Ketoglutarate and α-Ketoglutaramate in Assessing the Progression of Chronic Hepatoencephalopathy
by: Yevgeniya I. Shurubor, et al.
Published: (2024-02-01)

Metabolic Profiling of Cochlear Organoids Identifies α‐Ketoglutarate and NAD+ as Limiting Factors for Hair Cell Reprogramming
by: Qing Liu, et al.
Published: (2024-09-01)

mTOR/α-ketoglutarate signaling: impact on brain cell homeostasis under ischemic conditions
by: Iryna Lushnikova, et al.
Published: (2023-05-01)

A Study on the Efficient Preparation of α-Ketoglutarate with L-Glutamate Oxidase
by: Shuhui Niu, et al.
Published: (2024-04-01)

Dietary α-ketoglutarate alleviates glycinin and β-conglycinin induced damage in the intestine of mirror carp (Cyprinus carpio)
by: Qiaohua Luo, et al.
Published: (2023-04-01)

α-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1α/Nrf2 pathway
by: Danyu Cheng, et al.
Published: (2024-08-01)

Changes and significance of α kinase 1 expression in cartilage tisssueof patients with knee osteoarthritis
by: GENG Qinghe*, LAN Junyun, WANG Shen, HENG Ke, SONG Xingchen, NIE Peiru, ZHANG Huanyu, LIU Yanhong, GUO Yilong
Published: (2024-01-01)

Effects of dietary α-ketoglutarate supplementation on growth performance, digestive enzyme activity, immune gene expression, and intestinal morphology of largemouth bass (Micropterus salmoides) fed high soybean diet
by: Dujuan Zheng, et al.
Published: (2025-04-01)

The repair effect of α-ketoglutarate combined with mesenchymal stem cells on osteoarthritis via the hedgehog protein pathway
by: Liyan Li, et al.
Published: (2025-03-01)

HPV18 E6 inhibits α‐ketoglutarate‐induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway
by: Duo Tang, et al.
Published: (2023-08-01)

Nanoengineered cargo with targeted in vivo Foxo3 gene editing modulated mitophagy of chondrocytes to alleviate osteoarthritis
by: Manyu Chen, et al.
Published: (2025-01-01)

The Protective Role of Alpha-Ketoglutaric Acid on the Growth and Bone Development of Experimentally Induced Perinatal Growth-Retarded Piglets
by: Ewa Tomaszewska, et al.
Published: (2021-01-01)

Efficient Oxidative Desulfurization of High-Sulfur Diesel via Peroxide Oxidation Using Citric, Pimelic, and α-Ketoglutaric Acids
by: Barham Sharif Ahmed, et al.
Published: (2023-03-01)

Alpha-Ketoglutarate: An Effective Feed Supplement in Improving Bone Metabolism and Muscle Quality of Laying Hens: A Preliminary Study
by: Ewa Tomaszewska, et al.
Published: (2020-12-01)

The Role of the Rare Variants in the Genes Encoding the Alpha-Ketoglutarate Dehydrogenase in Alzheimer’s Disease
by: Dora Csaban, et al.
Published: (2021-04-01)

Expression Profile of Brain Aging and Metabolic Function are Altered by Resveratrol or α-Ketoglutarate Supplementation in Rats Fed a High-Fat Diet
by: Paulina Szczurek-Janicka, et al.
Published: (2021-07-01)

Putative mitochondrial α-ketoglutarate-dependent dioxygenase Fmp12 controls utilization of proline as an energy source in Saccharomyces cerevisiae
by: Ikuhisa Nishida, et al.
Published: (2016-09-01)

Electroacupuncture Exerts Chondroprotective Effect in Knee Osteoarthritis of Rabbits Through the Mitophagy Pathway
by: Xing L, et al.
Published: (2023-08-01)

Enzymatic Synthesis of Biologically Active <i>H</i>-Phosphinic Analogue of α-Ketoglutarate
by: Vsevolod L. Filonov, et al.
Published: (2024-12-01)

PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis
by: Xiang Xue, et al.
Published: (2023-08-01)

JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy
by: Ya Xie, et al.
Published: (2025-03-01)

α-Ketoglutarate stimulates cell growth through the improvement of glucose and glutamine metabolism in C2C12 cell culture
by: Bingquan Yang, et al.
Published: (2023-05-01)

The Potential Neurological Impact of Intraoperative Hyponatremia Using Histidine–Tryptophan–Ketoglutarate Cardioplegia Infusion in Adult Cardiac Surgery
by: Yu-Ning Hu, et al.
Published: (2024-06-01)

Reverse and Forward Electron Flow-Induced H<sub>2</sub>O<sub>2</sub> Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote Knock Out Animals
by: Gergő Horváth, et al.
Published: (2022-07-01)

Alpha-ketoglutarate promotes alveolar bone regeneration by modulating M2 macrophage polarization
by: Yuhan Li, et al.
Published: (2023-06-01)

Selection of Producer of α-Ketoglutaric Acid from Ethanol-Containing Wastes and Impact of Cultivation Conditions
by: Svetlana V. Kamzolova, et al.
Published: (2022-07-01)

TNF‐α‐Induced KAT2A Impedes BMMSC Quiescence by Mediating Succinylation of the Mitophagy‐Related Protein VCP
by: Zepeng Su, et al.
Published: (2024-03-01)

Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives
by: Saghi Hakimi Naeini, et al.
Published: (2023-05-01)

Inhibition of CC chemokine receptor 1 ameliorates osteoarthritis in mouse by activating PPAR-γ
by: Hanqing Xu, et al.
Published: (2024-06-01)

Dietary Alpha-Ketoglutarate Supplementation Improves Bone Growth, Phosphorus Digestion, and Growth Performance in Piglets
by: Junquan Tian, et al.
Published: (2023-02-01)

Mitophagy—A New Target of Bone Disease
by: Zhipeng Zeng, et al.
Published: (2022-10-01)

Molecular mechanism of hypoxia and alpha-ketoglutaric acid on collagen expression in scleral fibroblasts
by: Yun Sun, et al.
Published: (2024-10-01)

The Impact of Hyponatremia in Aortic Valve Surgery Using Histidine–Tryptophan–Ketoglutarate Cardioplegia
by: Ghiragosian Claudiu, et al.
Published: (2024-09-01)

Apigenin suppresses osteoarthritis progression by inhibiting pyroptosis via SIRT1/mTOR pathway-mediated mitophagy
by: Jiahao Ying, et al.
Published: (2025-01-01)

Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond
by: Guo L, et al.
Published: (2022-06-01)

Defective function of α-ketoglutarate dehydrogenase exacerbates mitochondrial ATP deficits during complex I deficiency
by: Gerardo G. Piroli, et al.
Published: (2023-11-01)

Identification of mitophagy‐related biomarkers in osteoarthritis
by: Shiqiang Ruan, et al.
Published: (2024-12-01)