A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity

A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity

The TLR/IL-1R pathway is a critical signaling module that is misregulated in pathologies like inflammation and cancer. Extracts from turmeric (Curcuma longa L.) enriched in curcumin and carbonyls like turmerones have been shown to exert potent anti-inflammatory effects. The present study evaluated t...

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Bibliographic Details
Main Authors: Minakshi Rana, Preeti Maurya, Sukka Santosh Reddy, Vishal Singh, Hafsa Ahmad, Anil Kumar Dwivedi, Madhu Dikshit, Manoj Kumar Barthwal
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Pharmacology
Subjects:
Endotoxemia
caspase-3
mitochondrial membrane potential
Chemically Modified Curcuma longa Extract
Interleukin-1 receptor-associated kinase 1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00223/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00223/full

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