Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing

Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylases, which have been linked to the pathogenesis of numerous diseases, including HIV, metabolic disorders, neurodegeneration and cancer. Docking of the virtual pan-African natural products library (p-ANAPL), fo...

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Bibliographic Details
Main Authors: Berin Karaman, Zayan Alhalabi, Sören Swyter, Shetonde O. Mihigo, Kerstin Andrae-Marobela, Manfred Jung, Wolfgang Sippl, Fidele Ntie-Kang
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
bichalcones
sirtuin inhibitors
virtual screening
Online Access:http://www.mdpi.com/1420-3049/23/2/416

Internet

http://www.mdpi.com/1420-3049/23/2/416

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