Natural compounds from freshwater mussels disrupt fungal virulence determinants and influence fluconazole susceptibility in the presence of macrophages in Cryptococcus neoformans

ABSTRACTCryptococcus neoformans is a human fungal pathogen responsible for fatal infections, especially in patients with a depressed immune system. Overexposure to antifungal drugs due to prolonged treatment regimens and structure-similar applications in agriculture have weakened the efficacy of cur...

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Bibliographic Details
Main Authors: Davier Gutierrez-Gongora, Michael Woods, Ryan S. Prosser, Jennifer Geddes-McAlister
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:Microbiology Spectrum
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02841-23