Mechanism of partial agonism in AMPA-type glutamate receptors
Partial agonists weakly activate receptors even when occupying all available binding sites. Here the authors show that partial agonists of the AMPA receptor drive the adoption of multiple inactive forms, accounting for their limited efficacy.
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14327 |