Infections and immune dysregulation in ataxia-telangiectasia children with hyper-IgM and non-hyper-IgM phenotypes: A single-center experience

Infections and immune dysregulation in ataxia-telangiectasia children with hyper-IgM and non-hyper-IgM phenotypes: A single-center experience

Ataxia-telangiectasia (A-T) is a severe syndromic neurodegenerative inborn error of immunity characterized by DNA reparation defect, chromosomal instability, and hypersensitivity to ionizing radiation, thereby predisposing affected individuals to malignant transformation. While the leading disease s...

Full description

Bibliographic Details
Main Authors: Aleksandra Szczawińska-Popłonyk, Katarzyna Tąpolska-Jóźwiak, Eyal Schwartzmann, Barbara Pietrucha
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pediatrics
Subjects:
ataxia-telangiectasia
inborn errors of immunity
syndromic immunodeficiency
infection
immune dysregulation
malignancy
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.972952/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2022.972952/full

Similar Items