Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients

Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients

Breast cancer risk is 31% heritable, yet the majority of the underlying risk factors remain poorly defined. Here, we used F2-linkage analysis in a rat mammary tumor model to identify a novel 11.2 Mb modifier locus of tumor incidence and burden on rat chromosome 5 (chr5: 15.4 – 26.6 Mb). Genomic and...

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Bibliographic Details
Main Authors: Cody Plasterer, Shirng-Wern Tsaih, Angela Lemke, Rebecca Schilling, Melinda Dwinell, Andrea Rau, Paul Auer, Hallgeir Rui, Michael J. Flister
Format: Article
Language:English
Published: Oxford University Press 2019-05-01
Series:G3: Genes, Genomes, Genetics
Subjects:
breast cancer
risk
incidence
outcome
TCGA
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200873

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200873

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