The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients

The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients

Abstract Background Cisplatin is one of the major drugs that used in the treatment of osteosarcoma. Cisplatin exerts its function by making cisplatin-DNA adducts culminating in cellular death. These adducts found to be repaired by nucleotide excision repair (NER) pathway. This study aimed to evaluat...

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Detaylı Bibliyografya
Asıl Yazarlar: Hadeel Obiedat, Nasr Alrabadi, Eyad Sultan, Marwa Al Shatti, Malek Zihlif
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: BMC 2018-07-01
Seri Bilgileri:BMC Medical Genetics
Konular:
Pharmacogenomics
Cisplatin
Osteosarcoma
ERCC1
ERCC2
Online Erişim:http://link.springer.com/article/10.1186/s12881-018-0627-4

Internet

http://link.springer.com/article/10.1186/s12881-018-0627-4

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