Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib)

Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib)

<p>Abstract</p> <p>Background</p> <p>Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemias (Ph-positive ALL) with clinically approved inhibitors of the Bcr/Abl tyrosine kinase frequently results in the emergence of a leukemic clone carrying the T31...

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Bibliographic Details
Main Authors: Fei Fei, Lim Min, Schmidhuber Sabine, Moll Jürgen, Groffen John, Heisterkamp Nora
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Molecular Cancer
Subjects:
Ph-positive
Aurora kinase inhibition
Drug resistance
Stromal support
Co-culture
Farnesyltransferase inhibitor, Lonafarnib
Dasatinib, p53, Combination drug treatment
Online Access:http://www.molecular-cancer.com/content/11/1/42

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http://www.molecular-cancer.com/content/11/1/42

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