Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis

Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis

Experimental autoimmune uveitis (EAU), a model of human uveitis, is an organ-specific, T cell-mediated autoimmune disease. Autoreactive T cells can penetrate the blood-retinal barrier, which is a physical defense composed of tight junction-linked retinal pigment epithelial (RPE) cells. RPE cells ser...

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Bibliographic Details
Main Authors: Sheng-Min Lo, Yih-Shiou Hwang, Chao-Lin Liu, Chia-Ning Shen, Wei-Hsin Hong, Wei-Cheng Yang, Meng-Hua Lee, Chia-Rui Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
autoimmune uveitis
barrier function
EAU
IL-17
RPE
TLR7
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.736261/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.736261/full

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