β-Mangostin suppresses LA-7 cells proliferation in vitro and in vivo: Involvement of antioxidant enzyme modulation; suppression of matrix metalloproteinase and α6β4 integrin signalling pathways

β-Mangostin suppresses LA-7 cells proliferation in vitro and in vivo: Involvement of antioxidant enzyme modulation; suppression of matrix metalloproteinase and α6β4 integrin signalling pathways

β-mangostin (βM) was isolated from Cratoxylum arborescens to investigate anti-breast cancer effect in vitro and in vivo. βM exhibited an inhibitory effect on the growth of LA-7 cells in vitro with apoptosis formation. In the animal model, βM treatment was found to be effective in improving the tissu...

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Bibliographic Details
Main Authors: Suvitha Syam, Ahmad Bustamam, Najihah Mohd Hashim, Mostafa Ghaderian, Yahya Hasan Hobani, Anwar Makeen, Siddig Ibrahim Abdelwahab, Syam Mohan
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Journal of Functional Foods
Subjects:
β-Mangostin
Breast cancer
MMP
α6β4 integrin
Apoptosis
Tamoxifen
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616000608

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http://www.sciencedirect.com/science/article/pii/S1756464616000608

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