An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis

An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis

Breakdown of neuromuscular junctions (NMJs) is an early pathological hallmark of amyotrophic lateral sclerosis (ALS) that blocks neuromuscular transmission, leading to muscle weakness, paralysis and, ultimately, premature death. Currently, no therapies exist that can prevent progressive motor neuron...

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Bibliographic Details
Main Authors: J Barney Bryson, Alexandra Kourgiantaki, Dai Jiang, Andreas Demosthenous, Linda Greensmith
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
regenerative medicine
motor neurons
optogenetics
Amyotrophic Lateral Sclerosis
paralysis
cell transplant
Online Access:https://elifesciences.org/articles/88250

Internet

https://elifesciences.org/articles/88250

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