Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma

Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma

Abstract Background Progranulin (PGRN), a glycoprotein secreted by a wide range of epithelial cells and plays an important role in inflammatory mechanisms and tumor progression. In this study, the expression, and functions of PGRN in papillary thyroid carcinoma (PTC) was examined to explore the pote...

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Bibliographic Details
Main Authors: Yanxu Dong, Hao Tan, Lidong Wang, Zhen Liu
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cancer Cell International
Subjects:
Thyroid neoplasm
JAK2-STAT3/4 pathway
Progranulin
Invasion
Apoptosis
JSI-124
Online Access:https://doi.org/10.1186/s12935-023-03033-2

Internet

https://doi.org/10.1186/s12935-023-03033-2

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