IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse

IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse

PurposeTo investigate IL-17 related mechanisms for developing dry eye disease in the Pinkie mouse strain with a loss of function RXRα mutation.MethodsMeasures of dry eye disease were assessed in the cornea and conjunctiva. Expression profiling was performed by single-cell RNA sequencing (scRNA-seq)...

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Main Authors: Jehan Alam, Ghasem Yazdanpanah, Rinki Ratnapriya, Nicholas Borcherding, Cintia S. de Paiva, DeQuan Li, Rodrigo Guimaraes de Souza, Zhiyuan Yu, Stephen C. Pflugfelder
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Medicine
Subjects:
gamma delta (gammadelta) T cells
conjunctiva
dry eye
IL-17
retinoic acid
RXR alpha
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.849990/full

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https://www.frontiersin.org/articles/10.3389/fmed.2022.849990/full

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