Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells
Abstract Naïve T (Tn) cells require two homeostatic signals for long-term survival: tonic T cell receptor:self-peptide–MHC contact and IL-7 stimulation. However, how microbial exposure impacts Tn homeostasis is still unclear. Here we show that infections can lead to the expansion of a subpopulation...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25645-w |