Microbial Tryptophan Metabolites Ameliorate Ovariectomy‐Induced Bone Loss by Repairing Intestinal AhR‐Mediated Gut‐Bone Signaling Pathway

Microbial Tryptophan Metabolites Ameliorate Ovariectomy‐Induced Bone Loss by Repairing Intestinal AhR‐Mediated Gut‐Bone Signaling Pathway

Abstract Microbial tryptophan (Trp) metabolites acting as aryl hydrocarbon receptor (AhR) ligands are shown to effectively improve metabolic diseases via regulating microbial community. However, the underlying mechanisms by which Trp metabolites ameliorate bone loss via gut‐bone crosstalk are largel...

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Bibliographic Details
Main Authors: Chuan Chen, Zheng Cao, Hehua Lei, Cui Zhang, Mengjing Wu, Shaohua Huang, Xinzhi Li, Denghui Xie, Maili Liu, Limin Zhang, Gang Chen
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
aryl hydrocarbon receptor (AhR)
gut microbiota
gut‐bone axis
IL‐10
tryptophan (Trp) metabolites
Wnt/β‐catenin signaling
Online Access:https://doi.org/10.1002/advs.202404545

Internet

https://doi.org/10.1002/advs.202404545

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