The Selective Agonist for Sphingosine-1-Phosphate Receptors Siponimod Increases the Expression Level of <i>NR4A</i> Genes in Microglia Cell Line

The Selective Agonist for Sphingosine-1-Phosphate Receptors Siponimod Increases the Expression Level of <i>NR4A</i> Genes in Microglia Cell Line

Fingolimod (FTY720) and siponimod (BAF312) are selective agonists for sphingosine-1-phosphate (S1P) receptors approved for the treatment of relapsing–remitting (RR) and secondary progressive (SP) multiple sclerosis (MS), respectively. BAF312 exerts pro-myelination and neuro-protective functions on C...

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Bibliographic Details
Main Authors: Francesca Montarolo, Serena Martire, Fabiana Marnetto, Paola Valentino, Sabdi Valverde, Marco Alfonso Capobianco, Antonio Bertolotto
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Current Issues in Molecular Biology
Subjects:
multiple sclerosis
<i>NR4A</i>
NURR1
sphingosine-1-phosphate (S1P) receptors
siponimod
fingolimod
Online Access:https://www.mdpi.com/1467-3045/44/3/83

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https://www.mdpi.com/1467-3045/44/3/83

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