Accurate genome-wide genotyping from archival tissue to explore the contribution of common genetic variants to pre-cancer outcomes

Accurate genome-wide genotyping from archival tissue to explore the contribution of common genetic variants to pre-cancer outcomes

Abstract Purpose The contribution of common genetic variants to pre-cancer progression is understudied due to long follow-up time, rarity of poor outcomes and lack of available germline DNA collection. Alternatively, DNA from diagnostic archival tissue is available, but its somatic nature, limited q...

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Bibliographic Details
Main Authors: Daniela Nachmanson, Meghana Pagadala, Joseph Steward, Callie Cheung, Lauryn Keeler Bruce, Nicole Q. Lee, Thomas J. O’Keefe, Grace Y. Lin, Farnaz Hasteh, Gerald P. Morris, Hannah Carter, Olivier Harismendy
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Translational Medicine
Subjects:
Low-coverage whole-genome sequencing
Breast cancer
Ductal carcinoma in situ
Polygenic risk score
Pre-cancer
Genotyping
Online Access:https://doi.org/10.1186/s12967-022-03810-z

Internet

https://doi.org/10.1186/s12967-022-03810-z

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