Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux via Up-regulation of SIRT1

Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux via Up-regulation of SIRT1

Hyperglycemia, a key characteristic and risk factor for diabetes mellitus (DM), causes neuronal senescence. Hydrogen sulfide (H2S) is a novel neuroprotectant. The present work was to investigate the potential effect of H2S on hyperglycemia-induced neuronal senescence and the underlying mechanisms. W...

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Bibliographic Details
Main Authors: Lei Wu, Ying Chen, Chun-Yan Wang, Yi-Yun Tang, Hong-Lin Huang, Xuan Kang, Xiang Li, Yu-Rong Xie, Xiao-Qing Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
hydrogen sulfide
high glucose
SIRT1
autophagic flux
neuronal senescence
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00194/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00194/full

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