The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery

The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery

Abstract Background Retinitis pigmentosa is the prevailing genetic cause of blindness in developed nations with no effective treatments. In the pursuit of unraveling the intricate dynamics underlying this complex disease, mechanistic models emerge as a tool of proven efficiency rooted in systems bio...

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Bibliographic Details
Main Authors: Marina Esteban-Medina, Carlos Loucera, Kinza Rian, Sheyla Velasco, Lorena Olivares-González, Regina Rodrigo, Joaquin Dopazo, Maria Peña-Chilet
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Retinitis pigmentosa
Rare diseases
Drug-repurposing
Disease maps
GABAergic neurotransmission
Systems medicine
Online Access:https://doi.org/10.1186/s12967-024-04911-7

Internet

https://doi.org/10.1186/s12967-024-04911-7

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