Impact of sodium butyrate and mild hypothermia on metabolic and physiological behaviour of CHO TF 70R cells

Impact of sodium butyrate and mild hypothermia on metabolic and physiological behaviour of CHO TF 70R cells

Background: To reduce costs associated with productivity of recombinant proteins in the biopharmaceutical industry, research has been focused on regulatory principals of growth and survival during the production phases of the cell culture. The main strategies involve the regulation of cell prolifera...

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Bibliographic Details
Main Authors: Veronica Avello, Bethzabeth Tapia, Mauricio Vergara, Cristian Acevedo, Julio Berrios, Juan G. Reyes, Claudia Altamirano
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Electronic Journal of Biotechnology
Subjects:
Cell cycle modulation
Cell viability
Chinese hamster ovary
Combined effect
Cytotoxic
Mitochondrial membrane potential
Recombinant human tissue plasminogen activator
Recombinant proteins
Regulation of cell proliferation
rh-tPA production
Sodium butyrate
Online Access:http://www.sciencedirect.com/science/article/pii/S0717345817300167

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http://www.sciencedirect.com/science/article/pii/S0717345817300167

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