Multiparametric in vivo analyses of the brain and spine identify structural and metabolic biomarkers in men with adrenomyeloneuropathy

Multiparametric in vivo analyses of the brain and spine identify structural and metabolic biomarkers in men with adrenomyeloneuropathy

Objective: Progressive myelopathy causes severe handicap in men with adrenomyeloneuropathy (AMN), an X-linked disorder due to ABCD1 pathogenic variants. At present, treatments are symptomatic but disease-modifying therapies are under evaluation. Given the small effect size of clinical scales in AMN,...

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Bibliographic Details
Main Authors: Isaac M. Adanyeguh, Xiaofang Lou, Eavan McGovern, Marie-Pierre Luton, Magali Barbier, Elise Yazbeck, Romain Valabregue, Dinesh Deelchand, Pierre-Gilles Henry, Fanny Mochel
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:NeuroImage: Clinical
Subjects:
Adrenomyeloneuropathy
Spinal cord imaging
Metabolite cycling
Fixel-based analysis
Imaging biomarkers
Spinal cord toolbox
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158221000103

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http://www.sciencedirect.com/science/article/pii/S2213158221000103

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