Discovery of Novel Andrographolide Derivatives as Antiviral Inhibitors against Human Enterovirus A71

Discovery of Novel Andrographolide Derivatives as Antiviral Inhibitors against Human Enterovirus A71

Hand-foot-and-mouth disease (HFMD) caused by human enterovirus A71 (EV-A71) infection has been associated with severe neurological complications. With the lack of an internationally approved antiviral, coupled with a surge in outbreaks globally, EV-A71 has emerged as a neurotropic virus of high clin...

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Bibliographic Details
Main Authors: Jie Kai Tan, Ran Chen, Regina Ching Hua Lee, Feng Li, Kun Dai, Guo-Chun Zhou, Justin Jang Hann Chu
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceuticals
Subjects:
human enterovirus A71
andrographolide
quinolinoxy
olefin
viral RNA replication
host-targeting
Online Access:https://www.mdpi.com/1424-8247/15/2/115

Internet

https://www.mdpi.com/1424-8247/15/2/115

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