Mesoporous Silica Nanoparticles Trigger Liver and Kidney Injury and Fibrosis Via Altering TLR4/NF-κB, JAK2/STAT3 and Nrf2/HO-1 Signaling in Rats

Mesoporous Silica Nanoparticles Trigger Liver and Kidney Injury and Fibrosis Via Altering TLR4/NF-κB, JAK2/STAT3 and Nrf2/HO-1 Signaling in Rats

Mesoporous silica nanoparticles (MSNs) represent a promising inorganic platform for multiple biomedical applications. Previous studies have reported MSNs-induced hepatic and renal toxicity; however, the toxic mechanism remains unclear. This study aimed to investigate MSNs-induced hepatic and nephrot...

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Bibliographic Details
Main Authors: Ayman M. Mahmoud, Ekram M. Desouky, Walaa G. Hozayen, May Bin-Jumah, El-Shaymaa El-Nahass, Hanan A. Soliman, Ahmed A. Farghali
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
mesoporous silica
nrf2
oxidative stress
fibrosis
nf-κb
Online Access:https://www.mdpi.com/2218-273X/9/10/528

Internet

https://www.mdpi.com/2218-273X/9/10/528

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