The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

ABSTRACT Lysyl-diacylglycerol (Lys-DAG) was identified three decades ago in Mycobacterium phlei, but the biosynthetic pathway and function of this aminoacylated lipid have since remained uncharacterized. Combining genetic methods, mass spectrometry, and biochemical approaches, we show that the multi...

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Bibliographic Details
Main Authors: Cameron P. Gill, Christopher Phan, Vivien Platt, Danielle Worrell, Thomas Andl, Hervé Roy
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
tRNA
diacylglycerol
Corynebacterium
Mycobacterium
antibiotic resistance
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01429-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01429-23

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