The role of epigenetic modifications in drug resistance and treatment of breast cancer
Abstract Background Breast cancer is defined as a biological and molecular heterogeneous disorder that originates from breast cells. Genetic predisposition is the most important factor giving rise to this malignancy. The most notable mutations in breast cancer occur in the BRCA1 and BRCA2 genes. Owi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Cellular & Molecular Biology Letters |
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| Online Access: | https://doi.org/10.1186/s11658-022-00344-6 |
| _version_ | 1818234958133592064 |
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| author | Mohsen Karami Fath Ali Azargoonjahromi Arash Kiani Fateme Jalalifar Parisa Osati Mahsa Akbari Oryani Fateh Shakeri Farhad Nasirzadeh Behman Khalesi Mohsen Nabi-Afjadi Hamidreza Zalpoor Maysam Mard-Soltani Zahra Payandeh |
| author_facet | Mohsen Karami Fath Ali Azargoonjahromi Arash Kiani Fateme Jalalifar Parisa Osati Mahsa Akbari Oryani Fateh Shakeri Farhad Nasirzadeh Behman Khalesi Mohsen Nabi-Afjadi Hamidreza Zalpoor Maysam Mard-Soltani Zahra Payandeh |
| author_sort | Mohsen Karami Fath |
| collection | DOAJ |
| description | Abstract Background Breast cancer is defined as a biological and molecular heterogeneous disorder that originates from breast cells. Genetic predisposition is the most important factor giving rise to this malignancy. The most notable mutations in breast cancer occur in the BRCA1 and BRCA2 genes. Owing to disease heterogeneity, lack of therapeutic target, anti-cancer drug resistance, residual disease, and recurrence, researchers are faced with challenges in developing strategies to treat patients with breast cancer. Results It has recently been reported that epigenetic processes such as DNA methylation and histone modification, as well as microRNAs (miRNAs), have potently contributed to the pathophysiology, diagnosis, and treatment of breast cancer. These observations have persuaded researchers to move their therapeutic approaches beyond the genetic framework toward the epigenetic concept. Conclusion Herein we discuss the molecular and epigenetic mechanisms underlying breast cancer progression and resistance as well as various aspects of epigenetic-based therapies as monotherapy and combined with immunotherapy. |
| first_indexed | 2024-12-12T11:46:20Z |
| format | Article |
| id | doaj.art-29c9525e846a461488f13da2288c2d89 |
| institution | Directory Open Access Journal |
| issn | 1425-8153 1689-1392 |
| language | English |
| last_indexed | 2024-12-12T11:46:20Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-29c9525e846a461488f13da2288c2d892022-12-22T00:25:27ZengBMCCellular & Molecular Biology Letters1425-81531689-13922022-06-0127112510.1186/s11658-022-00344-6The role of epigenetic modifications in drug resistance and treatment of breast cancerMohsen Karami Fath0Ali Azargoonjahromi1Arash Kiani2Fateme Jalalifar3Parisa Osati4Mahsa Akbari Oryani5Fateh Shakeri6Farhad Nasirzadeh7Behman Khalesi8Mohsen Nabi-Afjadi9Hamidreza Zalpoor10Maysam Mard-Soltani11Zahra Payandeh12Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi UniversityShiraz University of Medical SciencesStudent Research Committee, Yasuj University of Medical SciencesSchool of Medicine, Jiroft University of Medical SciencesChemical Engineering Department, Fouman Faculty of Engineering, College of Engineering, University of TehranDepartment of Pathology, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi UniversityDepartment of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi UniversityDepartment of Research and Production of Poultry Viral Vaccine, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension OrganizationDepartment of Biochemistry, Faculty of Biological Science, Tarbiat Modares UniversityShiraz Neuroscience Research Center, Shiraz University of Medical SciencesDepartment of Clinical Biochemistry, Faculty of Medical Sciences, Dezful University of Medical SciencesDepartment Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska InstituteAbstract Background Breast cancer is defined as a biological and molecular heterogeneous disorder that originates from breast cells. Genetic predisposition is the most important factor giving rise to this malignancy. The most notable mutations in breast cancer occur in the BRCA1 and BRCA2 genes. Owing to disease heterogeneity, lack of therapeutic target, anti-cancer drug resistance, residual disease, and recurrence, researchers are faced with challenges in developing strategies to treat patients with breast cancer. Results It has recently been reported that epigenetic processes such as DNA methylation and histone modification, as well as microRNAs (miRNAs), have potently contributed to the pathophysiology, diagnosis, and treatment of breast cancer. These observations have persuaded researchers to move their therapeutic approaches beyond the genetic framework toward the epigenetic concept. Conclusion Herein we discuss the molecular and epigenetic mechanisms underlying breast cancer progression and resistance as well as various aspects of epigenetic-based therapies as monotherapy and combined with immunotherapy.https://doi.org/10.1186/s11658-022-00344-6Breast cancerEpigenetic modificationsmicroRNAsTreatmentChemoresistance |
| spellingShingle | Mohsen Karami Fath Ali Azargoonjahromi Arash Kiani Fateme Jalalifar Parisa Osati Mahsa Akbari Oryani Fateh Shakeri Farhad Nasirzadeh Behman Khalesi Mohsen Nabi-Afjadi Hamidreza Zalpoor Maysam Mard-Soltani Zahra Payandeh The role of epigenetic modifications in drug resistance and treatment of breast cancer Cellular & Molecular Biology Letters Breast cancer Epigenetic modifications microRNAs Treatment Chemoresistance |
| title | The role of epigenetic modifications in drug resistance and treatment of breast cancer |
| title_full | The role of epigenetic modifications in drug resistance and treatment of breast cancer |
| title_fullStr | The role of epigenetic modifications in drug resistance and treatment of breast cancer |
| title_full_unstemmed | The role of epigenetic modifications in drug resistance and treatment of breast cancer |
| title_short | The role of epigenetic modifications in drug resistance and treatment of breast cancer |
| title_sort | role of epigenetic modifications in drug resistance and treatment of breast cancer |
| topic | Breast cancer Epigenetic modifications microRNAs Treatment Chemoresistance |
| url | https://doi.org/10.1186/s11658-022-00344-6 |
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