The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities

The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities

IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding. The final trimming of MHC-I epitopes is performed by two related a...

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Bibliographic Details
Main Authors: Adrian Martín-Esteban, Jesus Contreras Rodriguez, David Peske, Jose A. Lopez de Castro, Nilabh Shastri, Scheherazade Sadegh-Nasseri
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
HLA
antigen processing
aminopeptidase
peptidome
mechanism
epitope generation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1066483/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1066483/full

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