Antiangiogenic and Antitumoral Effects Mediated by a Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1)-Targeted DNAzyme

Antiangiogenic and Antitumoral Effects Mediated by a Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1)-Targeted DNAzyme

Abstract Antiangiogenesis is a promising antitumor strategy that inhibits tumor vascular formation to suppress tumor growth. DNAzymes are synthetic single-strand deoxyribonucleic acid (DNA) molecules that can cleave ribonucleic acids (RNAs). Here, we conducted a comprehensive in vitroselection of ac...

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Bibliographic Details
Main Authors: Liangfang Shen, Qin Zhou, Ying Wang, Weihua Liao, Yan Chen, Zhijie Xu, Lifang Yang, Lun-Quan Sun
Format: Article
Language:English
Published: BMC 2013-10-01
Series:Molecular Medicine
Subjects:
Vascular Endothelial Growth Factor Receptor
Tumor Microvascular Permeability
Ktrans
Ribonucleic Acid (RNA)
Matrigel Tube Formation Assay
Online Access:https://doi.org/10.2119/molmed.2013.00090

Internet

https://doi.org/10.2119/molmed.2013.00090

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