Inhibition of VEGF‐dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a

Inhibition of VEGF‐dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a

The C‐type lectin‐like domain of CLEC14a (CLEC14a‐C‐type lectin‐like domain [CTLD]) is a key domain that mediates endothelial cell–cell contacts in angiogenesis. However, the role of CLEC14a‐CTLD in pathological angiogenesis has not yet been clearly elucidated. In this study, through complementarity...

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Bibliographic Details
Main Authors: Taek‐Keun Kim, Chang Sik Park, Jihye Jang, Mi Ra Kim, Hee‐Jun Na, Kangseung Lee, Hyun Jung Kim, Kyun Heo, Byong Chul Yoo, Young‐Myeong Kim, Je‐Wook Lee, Su Jin Kim, Eun Sung Kim, Dae Young Kim, Kiweon Cha, Tae Gyu Lee, Sukmook Lee
Format: Article
Language:English
Published: Wiley 2018-03-01
Series:Molecular Oncology
Subjects:
angiogenesis
CLEC14a
CTLD
VEGF
tumor angiogenesis
Online Access:https://doi.org/10.1002/1878-0261.12169

Internet

https://doi.org/10.1002/1878-0261.12169

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