Lysine Demethylase KDM2A Promotes Proteasomal Degradation of TCF/LEF Transcription Factors in a Neddylation-Dependent Manner

Lysine Demethylase KDM2A Promotes Proteasomal Degradation of TCF/LEF Transcription Factors in a Neddylation-Dependent Manner

Canonical Wnt signaling is essential for a plethora of biological processes ranging from early embryogenesis to aging. Malfunctions of this crucial signaling pathway are associated with various developmental defects and diseases, including cancer. Although TCF/LEF transcription factors (TCF/LEFs) ar...

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Bibliographic Details
Main Authors: Tijana Šopin, František Liška, Tomáš Kučera, Dušan Cmarko, Tomáš Vacík
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
KDM2A
canonical Wnt signaling
TCF/LEF
ubiquitination
neddylation
Online Access:https://www.mdpi.com/2073-4409/12/22/2620

Internet

https://www.mdpi.com/2073-4409/12/22/2620

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