A GM-CSF and DOX co-delivery nanoplatform modulates macrophage polarization to promote tumor suppression

A GM-CSF and DOX co-delivery nanoplatform modulates macrophage polarization to promote tumor suppression

The immunosuppressive tumor microenvironment often compromises chemotherapeutic efficacy. Tumor-associated macrophages (TAM) are a critical component of the tumor immune microenvironment, a large portion of which is in M2-polarization with immunosuppressive effects. Priming the TAM to M1 polarizatio...

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Bibliographic Details
Main Authors: Miao Wang, Jiayu Zhang, Jiaruo Tang, Xiaomeng Cai, Rui Dou, Chen Guo, Yi Hu, Jun Chen
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:JCIS Open
Subjects:
Granulocyte-macrophage colony stimulating factor (GM-CSF)
DOX
Chemotherapy
Tumor immunity
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2666934X23000089

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http://www.sciencedirect.com/science/article/pii/S2666934X23000089

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