AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

AM-2201 is a synthetic cannabinoid that acts as a potent agonist at cannabinoid receptors and its abuse has increased. However, there are no reports of the inhibitory effect of AM-2201 on human cytochrome P450 (CYP) or uridine 5′-diphospho-glucuronosyltransferase (UGT) enzymes. We evaluated the inhi...

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Bibliographic Details
Main Authors: Ju-Hyun Kim, Soon-Sang Kwon, Tae Yeon Kong, Jae Chul Cheong, Hee Seung Kim, Moon Kyo In, Hye Suk Lee
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Molecules
Subjects:
AM-2201
cytochrome P450 inhibition
UDP-glucuronosyltransferase inhibition
human liver microsomes
drug-drug interaction
Online Access:http://www.mdpi.com/1420-3049/22/3/443

Internet

http://www.mdpi.com/1420-3049/22/3/443

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