Long-range structural preformation in yes-associated protein precedes encounter complex formation with TEAD

Summary: Yes-associated protein (YAP) is a partly intrinsically disordered protein (IDP) that plays a major role as the downstream element of the Hippo pathway. Although the structures of the complex between TEA domain transcription factors (TEADs) and the TEAD-binding domain of YAP are already well...

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Bibliographic Details
Main Authors: Michael Feichtinger, Andreas Beier, Mario Migotti, Matthias Schmid, Fedir Bokhovchuk, Patrick Chène, Robert Konrat
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222003698