Immunometabolic factors in adolescent chronic disease are associated with Th1 skewing of invariant Natural Killer T cells

Abstract Invariant Natural Killer T (iNKT) cells respond to the ligation of lipid antigen-CD1d complexes via their T-cell receptor and are implicated in various immunometabolic diseases. We considered that immunometabolic factors might affect iNKT cell function. To this end, we investigated iNKT cel...

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Bibliographic Details
Main Authors: Francesca A. Ververs, Suzanne E. Engelen, Roos Nuboer, Bas Vastert, Cornelis K. van der Ent, Belinda van’t Land, Johan Garssen, Claudia Monaco, Marianne Boes, Henk S. Schipper
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-99580-7