Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model

Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model

BackgroundAccording to our previous study, the loss of inhibitory interneuron function contributes to central sensitization in chronic migraine (CM). Synaptic plasticity is a vital basis for the occurrence of central sensitization. However, whether the decline in interneuron-mediated inhibition prom...

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Bibliographic Details
Main Authors: Xiaoxu Zeng, Yingying Niu, Guangcheng Qin, Dunke Zhang, Lixue Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
chronic migraine
inhibitory interneurons
GABABR2
NR2B
synaptic plasticity
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1142072/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1142072/full

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