The DNA Repair Enzyme Apurinic/Apyrimidinic Endonuclease (Apex Nuclease) 2 Has the Potential to Protect against Down-Regulation of Chondrocyte Activity in Osteoarthritis

The DNA Repair Enzyme Apurinic/Apyrimidinic Endonuclease (Apex Nuclease) 2 Has the Potential to Protect against Down-Regulation of Chondrocyte Activity in Osteoarthritis

Apurinic/apyrimidinic endonuclease 2 (Apex 2) plays a critical role in DNA repair caused by oxidative damage in a variety of human somatic cells. We speculated that chondrocyte Apex 2 may protect against the catabolic process of articular cartilage in osteoarthritis (OA). Higher levels of Apex 2 ex...

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Bibliographic Details
Main Authors: Naoko Yui, Hirotaka Yoshioka, Hiroto Fujiya, Haruki Musha, Moroe Beppu, Rie Karasawa, Kazuo Yudoh
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Molecular Sciences
Subjects:
osteoarthritis
DNA repair enzyme
oxidative stress
chondrocytes
Apex 2 (apurinic/apyrimidinic endonuclease 2)
Online Access:http://www.mdpi.com/1422-0067/15/9/14921

Internet

http://www.mdpi.com/1422-0067/15/9/14921

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